Applies only to oral form of both agents. Monofer 100mg/ml solution for injection/infusion - Summary of Product dexlansoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Individual plans may vary Administer ciprofloxacin at least 2 hours before or 6 hours after using these products. Brand name: Venofer Drug class: Iron Preparations Chemical name: iron saccharate CAS number: 8047-67-4 Medically reviewed by Drugs.com on Oct 25, 2022. David McAuley, Pharm.D. The two formulas used are presented below: Iron deficit in mg = Weight in kg x (14 Hb in g/dL) x 2.145, Volume of product required in mL = Iron deficit in mg / C in mg/mL. Applies only to oral form of both agents. DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. Applies only to oral form of both agents. Anemia of chronic disease (ACD), Calculation of the Total Iron Deficit equation appears in Cosmofer PI, Iron Dextran Dosing Calculator (iron deficit). The initial hemoglobin rise is more rapid with parenteral iron but on the long term (12 weeks), both therapies reach similar levels of hemoglobin. 20 mg/mL for Iron sucrose; 5 mg/mL for Ferric gluconate. The recipient will receive more details and instructions to access this offer. Minor/Significance Unknown. Administer a test INFeD dose prior to the first therapeutic dose. PDF Venofer - Food and Drug Administration DailyMed - VENOFER- IRON SUCROSE injection, solution The Ganzoni equation used by the iron deficiency calculator is the following: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores. iron sucrose decreases levels of minocycline by inhibition of GI absorption. Steps on how to print your input & results: 1. Applies only to oral form of both agents. Anemia. Administer Venofer 100 mg undiluted as a slow intravenous injection over 2 to 5 minutes, or as an infusion of 100 mg diluted in a maximum of 100 mL of 0.9% NaCl over a period of at least 15 minutes, per consecutive hemodialysis session [see How Supplied/Storage and Handling (16.2).] Dosage form: injection, solution Where: Medicine concentration Amount of active substance per a given volume of your drug. All Rights Reserved. Iron deficiency anemia calculator (diagnosis), Iron deficiency anemia vs. The therapeutic management of IDA focuses on the replenishment of the iron stores through methods that have been mentioned above. Most adults require a cumulative dose of elemental iron of at least 1 g. Iron replenishment is usually doneintravenously, via iron-dextran, iron sucrose or iron carboxymaltose. Intravenous Iron Therapy in Patients with Iron Deficiency Anemia FERAHEME Dosing & Administration - Feraheme Multiple placebo-controlled, randomized clinical trials have been conducted with IV iron in patients with New York Heart Association class II-III heart failure with an ejection fraction 45% who met criteria . Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Manage and view all your plans together even plans in different states. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. Baloxavir may bind to polyvalent cations resulting in decreased absorption. Intravenous iron sucrose for children with iron deficiency failing to Iron supplements, regardless of their way of administration, are used to replete body stores and to correct anemia. iron sucrose decreases levels of eltrombopag by inhibition of GI absorption. ]Venofer treatment may be repeated if iron deficiency reoccurs. FOR PATIENTS WEIGHING 50 kg OR MORE: Administer 1000 mg of Monoferric by intravenous infusion 20 minutes as a single dose 1. Your body may also need more iron if you use the drug erythropoietin to help make new red blood cells.Iron is an important part of your red blood cells and is needed to transport oxygen in the body. Avoid or Use Alternate Drug. Use alternatives if available. Minor/Significance Unknown. HONcode standard for trust- worthy health, Pediatric Oncology: Diagnosis And Prognosis Communication. Keep all medical and lab appointments. 1) Ganzoni AM. Applies only to oral form of both agents. iron sucrose increases levels of calcium carbonate by enhancing GI absorption. PDF Iron dosing and administration in adults backgrounder There are four variables, all patient parameters, required in the iron deficiency calculator: The patients weight is used in the Ganzoni equation and also when establishing the iron stores. cimetidine will decrease the level or effect of iron sucrose by increasing gastric pH. 10th ed. Applies only to oral form of both agents. Medicinal forms You will have to pay for your IV iron. Use Caution/Monitor. provider for the most current information. Iron deficit - equation derivation: Assumptions: -Blood volume = 65 mL/kg -Hemoglobin conc target =14.0 g/dL -Deficits in body stores are ignored. 1 ,*. By using this form you agree with the storage and handling of your data by this website. Fulminant symptoms may include general paleness, confusion or episodes of passing out. Our dosage calculator can help you with this as well. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. 2012;2(4):288-335. This cost includes the fee charged by the pharmacy. Applies only to oral form of both agents. Minor (1)iron sucrose decreases levels of manganese by inhibition of GI absorption. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvdmVub2Zlci1pcm9uLXN1Y3Jvc2UtMzQyMTYy, View explanations for tiers and Copyright 1993-2021 If no signs or symptoms of anaphylactic-type reactions follow the test dose, administer the full therapeutic INFeD dose. FERAHEME vs Venofer (iron sucrose) - Feraheme Minor/Significance Unknown.iron sucrose increases levels of calcium citrate by enhancing GI absorption. Last updated on Jun 1, 2022. Minor (2)calcium chloride decreases levels of iron sucrose by inhibition of GI absorption. Parenteral iron product is iron sucrose (C = 20 mg elemental iron/mL). Modify Therapy/Monitor Closely. Allow at least 30 minutes between administration of Feraheme and administration of other medications that could potentially cause serious hypersensitivity reactions and/or hypotension, such as chemotherapeutic agents or monoclonal antibodies. This may be helped by giving the medication more slowly or at a lower dose. Human studies not conducted. The recommended Feraheme dose may be readministered to patients with persistent or recurrent iron deficiency anemia. Symptoms associated with Venofer total dosage or infusing too rapidly included hypotension, dyspnea, headache, vomiting, nausea, dizziness, joint aches, paresthesia, abdominal and muscle pain, edema and cardiovascular collapse. Applies only to oral form of both agents. All adult and pediatric patients receiving Venofer require periodic monitoring of hematologic and iron parameters (hemoglobin, hematocrit, serum ferritin and transferrin saturation). Minor (1)iron sucrose, captopril. Calculation of total iron deficit for initial repletion: [29] Total cumulative dose (mg) = [Target Hb Actual Hb] weight (kg) 2.4 + [15 weight (kg)] *Hb in g/dl: 2. Applies only to oral form of both agents. Formula for calculating the required dose of iron sucrose Pregnancy: Risk Summary-Clinical Considerations. Minor (1)gymnema decreases levels of iron sucrose by inhibition of GI absorption. Use Caution/Monitor. Applies only to oral form of both agents. Avoid or Use Alternate Drug. Venofer (Iron Sucrose Injection): Uses, Dosage, Side Effects - RxList Consult your doctor for more details.Remember that it is best to get your vitamins and minerals from food whenever possible. Iron Injection Administration | INJECTAFER HCP didanosine will decrease the level or effect of iron sucrose by increasing gastric pH. Modify Therapy/Monitor Closely. Objective. PDF Protocol for the use of Intravenous Iron Dextran (CosmoFer STORAGE: Consult the product instructions and your pharmacist for storage details. Although the original formula requires the weight in kilograms, values input in lbs are transformed. Privacy Policy, Use 500 mg for adults and children 35 kg; use 15 mg/kg if <35 kg. restrictions. iron sucrose decreases levels of penicillamine by inhibition of GI absorption. Applies only to oral form of both agents. Applies only to oral form of both agents. HOW TO USE: This medication is given by injection into a vein as directed by your doctor. Use Caution/Monitor. Anemia caused by the depletion of iron is called iron deficiency anemia. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. If these effects continue or worsen, tell your doctor.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Iron Sucrose [ Venofer ] Elemental iron: 20 mg/mL (2.5 mL, 5 mL, 10 mL) Solution, Intravenous [preservative free]: [package insert] INDICATIONS: Venofer is an iron replacement product indicated for the treatment of iron deficiency anemia in patients with chronic kidney disease (CKD). Minor/Significance Unknown. Reference www.medicines.org.uk Background Applies only to oral form of both agents. Baloxavir may bind to polyvalent cations resulting in decreased absorption. Ren Fail. Venofer has not been studied in patients younger than 2 years old. DOSAGE AND ADMINISTRATION: Oral iron should be discontinued prior to administration of INFeD. Volume of iron product required = 25 mL. -Hgb deficit (grams) = Hgb deficit (g/dL) x blood volume (dL) -Iron deficit (mg) = Hgb deficit (grams) x 3.3 (mg Fe/g Hgb) [Note: 3.3 x 0.65 = 2.145] -Volume of parenteral iron product req'd (mL) = [Iron deficit (mg)] / C(mg/mL) Final calculations: -Hgb iron deficit (mg) = weight (kg) x (14 - Hgb) x (2.145) -Volume of product required (mL) = [weight (kg)x (14 - Hgb) x (2.145)] / C Where C= concentration of elemental iron (mg/ml) in the product being used: Iron dextran: 50 mg/mL. Fulminant symptoms include confusion, sensation of passing out, paleness. Am J HealthSyst Pharm 2006;63:731735. Do not administer Venofer to patients with iron overload. Avoid or Use Alternate Drug. Serious - Use Alternative (1)iron sucrose decreases levels of ofloxacin by inhibition of GI absorption. The dosing for iron replacement treatment in pediatric patients with hemodialysis-dependent chronic kidney disease (HDD-CKD), non-dialysis-dependent chronic kidney disease (NDD-CKD) or peritoneal-dialysis-dependent chronic kidney disease (PDD-CKD) has not been established. Sodium ferric gluconate complex injection [ Ferrlecit ] [package insert] - Elemental iron: 12.5 mg/mL (5 mL). Applies only to oral form of both agents. Do not dilute to concentrations below 1 mg/mL [see How Supplied/Storage and Handling (16.2).] Iron Deficiency in Heart Failure - Home - American College of Cardiology Applies only to oral form of both agents. Koch TA, Myers J, Goodnough LT. Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations. Use Caution/Monitor. Use Caution/Monitor. Nutrition. Each mL contains 20 mg of elemental iron. A patients lean body weight (or actual body weight if less than lean body weight) should be utilized when determining dosage. Recommended dosage for patients weighing less than 50kg (110lb): Give Injectafer in The usual adult total treatment course of Venofer is 1000 mg. Venofer treatment may be repeated if iron deficiency reoccurs. 1. Use Caution/Monitor. Volume of iron sucrose needed = 60 x (14 - 8) x (2.145) 20 = 38.6 mL . Alldredge BK, Corelli RL, Ernst ME, Guglielmo BJ, eds. Anemia of chronic disease (ACD), Calculation of the Total Iron Deficit equation appears in Cosmofer PI, Calculation of the Total Iron Deficit Alternative equation, Iron Dextran Dosing Calculator (iron deficit), HONcode standard for trust- worthy health, Pediatric Oncology: Diagnosis And Prognosis Communication, Pharmacosmos A/S, CosmoFer low molecular weight (Mw) iron dextran. Injection: 50 mg/2.5 mL, 100 mg/5 mL, or 200 mg/10 mL (20 mg/mL) in single-dose vials. US residents can call their local poison control center at 1-800-222-1222. PDF GUIDELINES FOR IRON INFUSION USE IN ADULTS - Brockville General Hospital Applies only to oral form of both agents. Use (s): Iron deficiency anemia in patients with chronic kidney disease (CKD) It is unlikely . aluminum hydroxide will decrease the level or effect of iron sucrose by increasing gastric pH. Minor/Significance Unknown. Applies only to oral form of both agents. Recommended dosing and infusion rates for PI. Each mL contains 20 mg of elemental iron. Applies only to oral form of both agents. Excessive therapy with parenteral iron can lead to excess storage of iron with the possibility of iatrogenic hemosiderosis. In case a pediatric patient with a weight below 35 kg is assessed, iron stores are calculated as 15 mg iron for each kg. Ferritin and transferrin are also recommended monitoring . It is important to note that the above calculations merely provide estimates and that individual dosage should be established by a medical professional based on the current package insert for the elemental iron product used. Iron sucrose can also be mixed in a saline solution and given through an IV over a longer time. Applies only to oral form of both agents. Applies only to oral form of both agents. 3) Auerbach M, Witt D, Toler W, Fierstein M, Lerner RG, Ballard H. (1988) Clinical use of the total dose intravenous infusion of iron dextran. The elemental iron product used is Iron sucrose 20 mg/mL. Adult Dosage and Administration: The recommended dosage of Ferrlecit for the repletion treatment of iron deficiency in hemodialysis patients is 10 mL of Ferrlecit (125 mg of elemental iron). Avoid or Use Alternate Drug. Injection site discoloration has been reported following extravasation. Monitor Closely (1)didanosine will decrease the level or effect of iron sucrose by increasing gastric pH. Iron Sucrose Protocol - Cmqcc Serious - Use Alternative (1)iron sucrose decreases levels of eltrombopag by inhibition of GI absorption. Administer iron products at least 2 hr before and no less than 6 hr after each dose to avoid chelation with magnesium. Have resuscitation equipment and personnel trained in the detection and treatment of anaphylactic-type reactions readily available during INFeD administration. ONE DOSE. Dosage: For patients weighing 50 kg (110 lb) or more: Give Injectafer in two doses separated by at least 7 days. Applies only to oral form of both agents. Avoid or Use Alternate Drug. Applies only to oral form of both agents. Bhowmik D, Modi G, Ray D, Gupta S, Agarwal SK, Tiwari SC, Dash SC. Foods rich in iron include meats (especially liver), eggs, raisins, figs, broccoli, brussels sprouts, beans, lentils, and iron-fortified or enriched cereals. Administer while the patient is in a reclined or semi-reclined position. iron sucrose decreases levels of deferiprone by enhancing GI absorption. NOTES: Lab and/or medical tests (such as complete blood count, ferritin, transferrin, total iron binding capacity-TIBC) should be done while you are using this medication. iron sucrose will decrease the level or effect of baloxavir marboxil by cation binding in GI tract. In this study and another study evaluating a single intravenous dose of iron sucrose containing 500-700 mg of iron in 26 anemic patients on erythropoietin therapy (23 female, 3 male; age range 16-60), approximately 5% of the iron was . Contact the applicable plan Slowing the infusion rate may alleviate symptoms. Give each dose as 750 mg for a total cumulative dose of 1500 mg of iron per course. Applies only to oral form of both agents. If we don't have the calculator you need we'll try to make it for you and add it to the website. Avoid or Use Alternate Drug. Schrier SL, Mentzer WC, Landaw SA. WARNING: RISK FOR SERIOUS HYPERSENSITIVITY/ANAPHYLAXIS REACTIONS Fatal and serious hypersensitivity reactions including anaphylaxis have occurred in patients receiving Feraheme. There is limited experience with administration of an infusion of 500 mg of Venofer, diluted in a maximum of 250 mL of 0.9% NaCl, over a period of 3.5 to 4 hours on Day 1 and Day 14 [see How Supplied/Storage and Handling (16.2). Indications: Feraheme is indicated for the treatment of iron deficiency anemia (IDA) in adult patients: who have intolerance to oral iron or have had unsatisfactory response to oral iron or who have chronic kidney disease (CKD). Anemia; 2015: 763576. Separate dosing of tetracyclines from these products. ANNA J. VENOFER (IRON SUCROSE INJECTION,USP) 100mg ELEMENTAL IRON - DailyMed Talk to your pharmacist for more details.During pregnancy, this medication should be used only when clearly needed. Case G. Maintaining iron balance with total-dose infusion of intravenous iron dextran. If either is present, do not use the liquid. PDF IRON PRODUCT CHOICE AND DOSE CALCULATION - Blood The dosing for iron replacement treatment in pediatric patients with NDD-CKD or PDD-CKD has not been established. The Ganzoni equation used by the iron deficiency calculator is the following: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores The recommendation is that most adults need a cumulative dose of elemental iron of at least 1 g. We'll do this entirely for free, as long as the calculator has applications for women's health. Use Caution/Monitor. Oral iron therapy is the first method while IV therapy comes in place when there are contraindications or the body doesnt respond to the oral one. Use Caution/Monitor. Applies only to oral form of both agents. You may report side effects to Health Canada at 1-866-234-2345. The iron deficit calculator is useful as one of the determinations performed before iron replenishment therapy is initiated. Deferasirox chelates iron. Medscape Education, Improving Quality of Care in Patients With Iron Deficiency Anemia and Inflammatory Bowel Disease, 2010feosol-carbonyl-fe-icar-c-carbonyl-iron-342171Drugs, encoded search term (iron sucrose (Venofer)) and iron sucrose (Venofer), Use of High-Dose Iron in Dialysis in US Tracks PIVOTAL Trial, FDA Watch List Adds Drugs With Anaphylaxis, Herpes, Fetal Death Risk, Dialysis Industry Mergers: Profits Rise as Patient Outcomes Worsen, Hematology-Oncology Guidelines: 2017 Midyear Review. Intravenous (IV) iron products (use in adults) Dosing information in this table is for adults and includes some dosing recommendations not listed in the approved product information. Intravenous iron sucrose: establishing a safe dose. Minor/Significance Unknown. LBW = Lean body weight in kg. Avoid or Use Alternate Drug. Applies only to oral form of both agents. For all products, slow initial infusion is prudent; the patient is observed closely for infusion reactions. When administering as a slow intravenous push, give at the rate of approximately 100 mg (2 mL) per minute. This medicine is sometimes given slowly, and the infusion can take up to 2.5 hours to complete. (See also Notes section. Option 2: 200 mg in NS 100 mL administered over 20-30 minutes; may repeat every other day to Use Caution/Monitor. Drug Dosing in Obesity Reference Table - ClinCalc.com The dose of Venofer must be individually calculated for each patient according to the total iron deficit calculated with the following Ganzoni formula, for example: Total iron deficit [mg] = BW [kg] x (target Hb - actual Hb) [g/dl] x 2.4* + storage iron [mg] Below 35 kg BW: 35 kg BW and above: Target Hb = 13 g/dl and storage iron = 15 mg/kg BW The dosage of Venofer is expressed in mg of elemental iron. Monitor Closely (1)sodium sulfate/potassium sulfate/magnesium sulfate decreases levels of iron sucrose by inhibition of GI absorption. There are three fields in the parenteral iron replacement for iron deficiency anemia calculator: Weight can be input in either lbs or kilograms and the required transformations are performed by the calculator. These are real scientific discoveries about the nature of the human body, which can be invaluable to physicians taking care of patients. Monitor Closely (1)iron sucrose decreases levels of ibandronate by inhibition of GI absorption. commonly, these are "non-preferred" brand drugs. Copyright 2021 GlobalRPH - Web Development by, Calculation of the Total Iron Deficit Alternative equation. This drug is available at the lowest co-pay. Injectafer treatment may be repeated if iron deficiency anemia reoccurs. DOSAGE AND ADMINISTRATION: The recommended dose of Feraheme is an initial 510 mg dose followed by a second 510 mg dose 3 to 8 days later. elemental iron (mg/ml) in the product being used: Where C= Intravenous iron sucrose: establishing a safe dose - PubMed Assessing new treatment options, Intravenous iron-dextran: therapeutic and experimental possibilities. Avoid or Use Alternate Drug. 3) Bayraktar UD, Bayraktar S. (2010) Treatment of iron deficiency anemia associated with gastrointestinal tract diseases. Applies only to oral form of both agents. Always ask your health care professional for complete information about this product and your specific health needs. Echocardiogram Z Score (NEW)(BETA TESTING) Edinburgh Postnatal Depression Scale. When iron sucrose was administered at deliberate overdoses to rabbit dams (up to 215 mg/kg/day) marked fetal/placental iron overload was noted. 1982;13(4):309-21. A target haemoglobin value is also input so iron deficit can be determined according to a specified individual target. Avoid or Use Alternate Drug. Then enter the value of the Dosage and choose the unit of measurement from the drop-down menu. All material on this website is protected by copyright, Copyright 1994-2023 by WebMD LLC. Mode of Administration: Administer Venofer only intravenously by slow injection or by infusion. Intravenous therapy is usually recommended in case of contraindications to oral iron, comorbidities that prevent absorption, chronic renal impairment or iron replacement needs to be rapid. Monitor Closely (1)pantoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Evaluate the hematologic response (hemoglobin, ferritin, iron and transferrin saturation) at least one month following the second Feraheme infusion. commonly, these are "non-preferred" brand drugs or specialty These adverse reactions have occurred up to 30 minutes after the administration of Venofer injection. iron sucrose decreases levels of liothyronine by inhibition of GI absorption. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. Use INFeD only in patients in whom clinical and laboratory investigations have established an iron deficient state not amenable to oral iron therapy. Applies only to oral form of both agents.
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