Then you may get smaller spots that sweep out from the middle of the body in a shape that looks like drooping pine-tree branches. This article presents a case of PR in a 66-year-old black male 1 week after administration of the Pfizer-BioNTech COVID-19 vaccine. Thirty-one studies were included for data extraction after screening following the eligibility criteria. Researchers Continue to Find Clues About MIS-C - Yale Medicine Federal government websites often end in .gov or .mil. 2022 Nov 6;15:2369-2382. doi: 10.2147/CCID.S388245. and transmitted securely. Manifestation of pityriasis rosea and pityriasis rosealike eruptions Pityriasis rosea: Signs and symptoms - American Academy of Dermatology Contributions: SV and CAM, conceived and wrote the article. Dermatol Reports. eCollection 2022. The site is secure. walker hayes daughter. We report 10 . J Am Acad Dermatol. In all patients laboratory examinations were within normal ranges. Immunity, Inflammation and Disease published by John Wiley & Sons Ltd. Please enable it to take advantage of the complete set of features! 8600 Rockville Pike Marcantonio-Santa Cruz OY, Vidal-Navarro Y, Pesqu D, et al.. Pityriasis rosea developing after COVID-19 vaccination. Conclusions: We report a spectrum of cutaneous reactions after mRNA COVID-19 vaccines. Limitations: Registry analysis does not measure incidence. and transmitted securely. Case Report: Pityriasis Rosea-Like Eruption Following COVID-19 Vaccination Once a person has pityriasis rosea, it rarely recurs. and transmitted securely. J Am Acad Dermatol. Pityriasis rosea is a rash that often begins as an oval spot on the face, chest, abdomen or back. Pityriasis rosea, pityriasis rosea-like eruptions, and herpes zoster in the setting of COVID-19 and COVID-19 vaccination. sharing sensitive information, make sure youre on a federal It has been reported that pityriasis rosea has been triggered by several vaccines, as a rare side-effect. The following self-care tips may help relieve the discomfort of pityriasis rosea: Take nonprescription allergy medicine (antihistamines), such as diphenhydramine (Benadryl, others). Abstract Dear Editor, Pityriasis rosea (PR) is a common, self-limited erythematous papulosquamous dermatosis that mainly affects young adults. Moreover, COVID-19 may solely induce human herpesvirus reactivation through the immunomodulatory ability of SARS-CoV-2 to reactivate latent viruses (8, 9). 8600 Rockville Pike government site. Unauthorized use of these marks is strictly prohibited. Cureus. A total of 111 people were identified to have developed pityriasis rosea or pityriasis rosea-like eruptions after vaccination, out of which 36 (55.38%) were female. Fortunately, PR-like eruption is responsive to topical corticosteroids without any systemic adverse effects. -, Broccolo F., Drago F., Careddu A.M., et al. Vaccine-Related Eruptions of Papules and Plaques Following COVID-19 Vaccination - A Case Series. Disclaimer. Vaccination is one of the cornerstones in the efforts towards ending the coronavirus disease 2019 (COVID-19) pandemic. Learning points: -, Busto-Leis J.M., Servera-Negre G., Mayor-Ibarguren A., et al. 2022 May;121(5):1003-1007. doi: 10.1016/j.jfma.2021.12.028. Oral baricitinib for moderate to severe alopecia areata in adolescents . Unauthorized use of these marks is strictly prohibited. (2017) 5:20311. Med. Clipboard, Search History, and several other advanced features are temporarily unavailable. Unable to load your collection due to an error, Unable to load your delegates due to an error. Why covid arm and other post-vaccine rashes might actually be a 'good JAAD Int. +39.3465909404. government site. The https:// ensures that you are connecting to the The authors of one 2014 case report of a 71-year-old man who suffered from pityriasis rosea one month after receiving an influenza vaccine concluded that "altered immunity" could result in. 2023 Mar 3;14(2):207-212. doi: 10.4103/idoj.idoj_449_22. (2021) 35:e5468. It manifests as oval-shaped, pink or red . The SARSCoV2 pandemic plagued the world over the course of the year. SARS-CoV-2 spike protein positivity in pityriasis rosea-like and urticaria-like rashes of COVID-19. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License (, Anti-SARS-CoV-2, AZD1222, BNT162b2, mRNA-1273, Pityriasis rosea, Pityriasis rosea-like eruption. 2021;35(9):e546e548. Careers, Unable to load your collection due to an error. Veraldi S, Boneschi V, Cusini M, Maronese CA. PMC Bin Rubaian NF, Almuhaidib SR, Aljarri SA, Alamri AS. National Library of Medicine . Clipboard, Search History, and several other advanced features are temporarily unavailable. Pearls and pitfalls: Adverse cutaneous reactions after COVID-19 vaccination. Involvement of the oral mucosa has also been reported in as many as 50% of all cases (11). government site. J Eur Acad Dermatol Venereol. Rashes Could Be 'Key Sign' Of Covid-19. Here's What They Look Like MeSH Careers. FOIA As a library, NLM provides access to scientific literature. Optimized Health and Wellness (Hudson) - Book Appointment Online! HHS Vulnerability Disclosure, Help However, in cases of atypical PR, it may present with erythema multiforme-like lesions and purpura (5). Suchonwanit P, Leerunyakul K, Kositkuljorn C. Diagnostic and prognostic values of cutaneous manifestations in COVID-19. Children | Free Full-Text | COVID-19 and Related Vaccinations in Veraldi S, Boneschi V, Cusini M, Maronese CA. Methods: Clipboard, Search History, and several other advanced features are temporarily unavailable. Pityriasis rosea after administration of Pfizer-BioNTech COVID-19 vaccine. (2020) 33:e13650. (2020) 33:e13878. Federal government websites often end in .gov or .mil. Cases of EM was observed after mRNA-based COVID-19 vaccines, and after CoronaVac vaccination wich is is an inactivated SARS-CoV-2 virus [13, 14]. COVID-19 is an infectious disease caused by SARS-CoV-2, which emerged in China in 2019 and rapidly spread worldwide to become a pandemic in March 2020. Hum Vaccin Immunother. Catal A, Muoz-Santos C, Galvn- Casas C, et al.. Cutaneous reactions after SARS-COV-2 vaccination: a crosssectional Spanish nationwide study of 405 cases, Pityriasis rosea-like eruption after Pfizer-BioNTech COVID-19 vaccination. -. The disease begins with a single erythematous plaque, the so-called herald patch that usually appears on the trunk: it is roundish, pink to red in color and remains the only clinical manifestation for some days, when widespread, clinically similar, although smaller lesions appear. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Some studies have identified severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike proteins on endothelial cells and lymphocytes from PR-like lesions, consistent with direct viral invasion (3, 4). How Does A Person Get Pityriasis Rosea? - eMedicineHealth Environ Sci Pollut Res. Pityriasis rosea (PR) is an acute, exanthematous disease likely caused by human herpesvirus (HHV)-6 and/or HHV-7. Post Covid-19 vaccination papulovesicular pityriasis rosea-like eruption in a young male. (2021). Data were independently extracted and accessed for bias. Pityriasis rosea-like eruption after Pfizer-BioNTech COVID-19 vaccination No HHV-6 and HHV-7 reactivation is detected. doi: 10.1111/bjd.20143. Potassium hydroxide, syphilis, and laboratory tests were within normal limits. The https:// ensures that you are connecting to the Pityriasis rosea is a common viral infection that usually affects individuals between 10-35 years of age. We present a case of a pityriasis rosea-like rash occurring after Pfizer COVID-19 vaccination and review cases of pityriasis rosea (PR)/PR-like eruption (PR-LE) after mRNA COVID-19 vaccine published in the medical literature. This table includes information on vaccines that have published phase 3 trial data in the peer reviewed literature and are provisionally approved by the Australian Government Therapeutic Goods Administration (TGA). Unfortunately, due to her deteriorating neurologic status, her associated symptoms were not evaluated properly. J Am Acad Dermatol. Dermatol Reports. It is increasingly recognized that SARS-CoV-2 infection and COVID-19 vaccines have been associated with skin disorders, including pityriasis rosea. -, Carballido Vzquez AM, Morgado B. Pityriasis rosea-like eruption after PfizerBioNTech COVID-19 vaccination. tivation is associated with pityriasis rosea-like eruption.6 Our cases of herpes simplex and pityriasis rosea-like eruption occurred in male patients following the first dose of BioNTech, whereas one female patient suffered herpes zoster following the third dose of CoronaVac. An official website of the United States government. and transmitted securely. sharing sensitive information, make sure youre on a federal Front. It often presents with diffuse and confluent severely pruritic dusky-red erythematous lesions in the absence of herald patch (11). Patient n. 1. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher. 2 min read January 12, 2022 - 6:26AM A Sydney-based woman has credited her booster dose of the Covid-19 vaccine with removing two persistent warts she's had for five years. COVID-19 vaccine hesitancy is a critical problem that hinders sharing sensitive information, make sure youre on a federal The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. In some cases, central hyperpigmentation was identified. Sprinkle bath water with an oatmeal-based bath product (Aveeno). The significance of investigating clinical, histopathologic and virological features in pityriasis rosea and pityriasis rosea-like eruptions following COVID-19 vaccinations. Cutaneous adverse reactions of COVID-19 vaccines: A systematic review. 2022 Jul 6;15(1):9503. doi: 10.4081/dr.2022.9503. Dermatol Reports. Careers. Dermatology. All patients are currently in good general health. It starts with one large round or oval scaly patch. Secukinumab for pityriasis rubra pilaris (December 2022) SKIN CANCER. Pityriasis Rosea-like eruptions following COVID-19 mRNA-1273 vaccination: A case report and literature review. UpToDate 2022 Aug;35(8):e15602. Bookshelf The ones found in people with pityriasis rosea are human herpesviruses 6 and 7. Due to the rising incidence of coronavirus disease 2019 (COVID-19) worldwide, mass vaccination has been the cornerstone in preventing viral spread and decreasing morbidity and mortality. Epub 2021 Sep 25. SARS-CoV-2 vaccine; cutaneous side-effects; infection; papulosquamous; skin diseases; vaccine hesitancy. She was prescribed outpatient COVID-19 treatment of azithromycin, vitamins D and C, and then quarantined for 2 weeks. Bookshelf Bethesda, MD 20894, Web Policies Copyright 2021 Leerunyakul, Pakornphadungsit and Suchonwanit. Suchonwanit P, Hector CE, Bin Saif GA, McMichael AJ. Pityriasis rosea-like eruptions following vaccination with BNT162b2 mRNA COVID-19 Vaccine. -. JAAD Case Rep. (2018) 4:8001. Pityriasis Rosea Induced by COVID-19 Vaccination Eur J Case Rep Intern Med. Pityriasis Rosea | Johns Hopkins Medicine If you develop pityriasis rosea, you may experience the following in this order: Feel ill for 1 or 2 days Develop a large patch on your skin Get many smaller patches or bumps on your skin See your skin clear the reactivation of varicella zoster or herpes simplex infections, pityriasis rosea or rosea-like lesions, petechiae, pernicious purpura . sharing sensitive information, make sure youre on a federal However, pityriasis rosea is a selflimiting benign exanthema and does not require . Federal government websites often end in .gov or .mil. Epub 2021 Jun 10. Bookshelf COVID19 MapJohns Hopkins Coronavirus Resource Center. The coronavirus disease 2019 (COVID-19) pandemic is filling the headlines these days. This site needs JavaScript to work properly. "Covid arm," a red, rashlike skin reaction that can occur at the injection site days after inoculation, has been well-publicized. Pityriasis Rosea Following Pfizer-BioNTech Vaccination in an Adolescent Girl. -, Johansen M, Chisolm SS, Aspey LD, Brahmbhatt M. Pityriasis rosea in otherwise asymptomatic confirmed COVID-19-positive patients: a report of 2 cases. Disclaimer. Disclaimer. This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! J Eur Acad Dermatol Venereol. doi: 10.1016/j.jdcr.2018.04.002, 12. Before Marcantonio-Santa Cruz OY, Vidal-Navarro A, Pesqu D, Gimnez-Arnau AM, Pujol RM, Martin-Ezquerra G. J Eur Acad Dermatol Venereol. The pathogenesis of this relationship is unknown. The exanthem was self-limited in both patients over a period of a month. Several vaccines have been created to counteract the morbidity and mortality associated with COVID19 and stop viral transmission, including the Moderna vaccine (Mrna1273).The mRNA1273 vaccine is a lipid nanoparticle-encapsulated mRNAbased vaccine that encodes the prefusion stabilized fulllength spike . -. Khan I, Elsanousi AA, Shareef AM, Tebha SS, Arif A, Gul S. Immun Inflamm Dis. Pityriasis rosea. Unable to load your collection due to an error, Unable to load your delegates due to an error. Pregnant women are in a high-risk group for serious complications from pityriasis rosea. Nevertheless, she did not present with fever or respiratory tract symptoms. Akdas E, Ilter N, Ogut B, Erdem O. Pityriasis rosea following CoronaVac COVID-19 vaccination: a case report. Bethesda, MD 20894, Web Policies These types cannot cause cold sores or genital herpes. eCollection 2023 Mar-Apr. The patients/participants provided their written informed consent to participate in this study. Ethical review and approval was not required for the study on human participants in accordance with the local legislation and institutional requirements. We speculate that PR could be a delayed skin manifestation of COVID-19 infection, triggered either by SARS-CoV-2 immediately or indirectly by the reactivation of other viruses such as HHV-6 or HHV-7. doi: 10.1016/j.jaad.2020.04.094, 8. J Eur Acad Dermatol Venereol 2016; 30: 544-545. Laboratory investigation results (i.e., complete blood count, blood chemistry, C-reactive protein level, erythrocyte sedimentation rate, serological test for syphilis, plasma polymerase chain reaction (PCR) for human herpesvirus (HHV)-6 and HHV-7, and reverse transcription-PCR for COVID-19) were unremarkable. Chanprapaph K, Pomsoong C, Tankunakorn J, Eden C, Suchonwanit P, Rutnin S. Comparative analyses of clinical features, histopathology, and CD123 immunohistochemistry of oral lupus erythematosus, lichen planus, and other lichenoid lesions. (2021) 85:4655. 2021;23(3):221228. However, adverse effects to COVID-19 vaccines, particularly cutaneous reactions, have been reported. FOIA doi: 10.1111/bjd.20143. 8600 Rockville Pike They are described as small, itchy blisters found on the trunk of the body and filling with blood, present in middle-aged patients. However, some hypotheses may be advanced: i) PR/PRLE following anti- Sars-CoV-2 vaccination may be just a coincidence, for instance in those patients in whom PR/PRLE appeared only one day after vaccination;4,12 ii) anti-Sars-CoV-2 vaccines cause a reactivation of HHV-6 and/or HHV-7, which is similar to the reported association with herpes zoster;1,9 iii) vaccines can induce a delayed hypersensitivity response clinically similar to druginduced PRLE.10. PR is a self-limiting exanthematous disease and herpes zoster is a treatable condition; therefore, their occurrence does not require discontinuation of the vaccination schedule. In 3 patients a biopsy for histopathological examinations was carried out. PDF Cutaneous reactions after CoronaVac and BioNTech vaccines Although the most severe manifestations concern the lower respiratory tract, COVID-19 is a multiorgan disease that also affects the skin. This is called a herald patch and may be up to 4 inches (10 centimeters) across. doi: 10.1159/000517971. Authors Lina Abdullah 1 2022 by the American Academy of Dermatology, Inc. -, Carballido Vzquez A.M., Morgado B. Pityriasis rosea-like eruption after Pfizer-BioNTech COVID-19 vaccination. Drug-induced PR-like eruption accounts for 2% of all cutaneous adverse drug reactions (10). Pityriasis rosea is a type of skin rash. The .gov means its official. Cebeci Kahraman F, Sava Erdoan S, Akta ND, Albayrak H, Trkmen D, Borlu M, Arca DA, Demirba A, Akbayrak A, Polat Ekinci A, Gkek GE, elik HA, Taolar MK, An , Temiz SA, Hazinedar E, Ayhan E, Hzl P, Solak E, Kl A, Ylmaz E. J Cosmet Dermatol. Cases of pityriasis rosea/pityriasis rosea-like eruption after anti-SARS-CoV-2 vaccination reported in the literature. Pityriasis rosea-like eruption after Pfizer-BioNTech COVID-19 vaccination Pityriasis rosea-like eruption after Pfizer-BioNTech COVID-19 vaccination Pityriasis rosea-like eruption after Pfizer-BioNTech COVID-19 vaccination Pityriasis rosea-like eruption after Pfizer-BioNTech COVID-19 vaccination Br J Dermatol. Complete remission was observed within 14-30 days. Please enable it to take advantage of the complete set of features! Federal government websites often end in .gov or .mil. Your Random Rash Could Be Pityriasis Rosea | Allure Following the national COVID-19 vaccination guidelines, she received a shot of ChAdOx1 nCoV-19 (AZD1222) vaccine before the therapy. 2022 Jun;7:164-168. doi: 10.1016/j.jdin.2022.01.009. Vaccinations have been identified to rarely cause several cutaneous reactions. J Eur Acad Dermatol Venereol 2020; 34: e436-e437. No report of Pityriasis rosea is found for people with Abdominal fullness prematurely after meals. Cyrenne BM, Al-Mohammedi F, DeKoven JG, Alhusayen R. J Eur Acad Dermatol Venereol. *Correspondence: Poonkiat Suchonwanit, poonkiat@hotmail.com, ORCID: Kanchana Leerunyakul orcid.org/0000-0002-0669-5611Kallapan Pakornphadungsit orcid.org/0000-0003-4783-0282Poonkiat Suchonwanit orcid.org/0000-0001-9723-0563, COVID-19 Associated Cutaneous Manifestations and COVID-19 Vaccine Related Skin Reactions, View all J Eur Acad Dermatol Venereol. Inclusion in an NLM database does not imply endorsement of, or agreement with, In a Turkish-Egyptian study, the average age was 44.9 years;17 iii) in 30 cases the vaccine used was BNT162b2, in 18 cases it was CoronaVac, in 4 cases it was AZD1222 and in 4 cases it was mRNA-1273; in 5 cases, the vaccine was generically defined as mRNA or recombinant. SV, CAM, MC, VB, collected the data. COVID-19; HHV, human herpes virus; Moderna; PR; PR, pityriasis rosea; PR-LE; PR-LE, pityriasis rosea-like eruption; Pfizer; coronavirus; dermatology; mRNA vaccine; mRNA, messenger RNA; pityriasis rosea; pityriasis rosealike eruption; vaccine. It is usually seen in children, adolescents, and young adults. PRISMA, preferred reporting. and transmitted securely. Would you like email updates of new search results? An official website of the United States government. The cause of pityriasis rosea is not known, but it is commonly believed to be caused by a virus or bacteria. There is a growing number of published cases that link PR to COVID-19 infection, with PR appearing either in the acute phase of COVID-19 or, as in our patient, in the post COVID-19 period (4-9). National Library of Medicine They described a patient developing pityriasis rosea (PR) 2 hours after the second dose of Moderna COVID-19 vaccination. doi: 10.1111/dth.13878, 10. In our study we observed 2 cases of EM after covid19 vaccine , one occurred after the BBIBP-CorV vaccine while the other was observed after ChAdOx1 nCoV- 19 vaccine. Pityriasis rosea - Diagnosis and treatment - Mayo Clinic Rosacea, Acne, Shingles, Covid-19 Rashes: Common Adult Skin - OnHealth Clin Dermatol. See this image and copyright information in PMC. Among patients who received inactivated vaccines, another case of PR-like eruption was reported four days after the first dose of CoronaVac (SinoVac) (1). Martora F, Battista T, Marasca C, Genco L, Fabbrocini G, Potestio L. Clin Cosmet Investig Dermatol. Accessibility Careers. Pityriasis rosea (PR), PR-like eruptions (PR-LE), and herpes zoster have been frequently reported during the COVID-19 pandemic and following COVID-19 vaccination. The mechanisms behind these COVID-19-related symptoms remain unclear. An official website of the United States government. The study is created by eHealthMe and uses data from the Food and Drug Administration (FDA). It can take 1 to 3 months to go away. Herald patch of pityriasis rosea. Within two weeks of topical betamethasone dipropionate treatment, the lesions disappeared completely. (2021) 35:e4913. HHS Vulnerability Disclosure, Help It is believed to represent a delayed reaction to viral infections and is usually associated with endogenous systemic reactivation of human herpesvirus (HHV) 6 and / or 7 (1). We observed Histopathologic examination revealed epidermal focal spongiosis, interface dermatitis with necrotic keratinocytes, perivascular lymphocytic infiltration, and few eosinophilic infiltrations in the superficial dermis (Figures 3B,C). . -, Cyrenne BM, Al-Mohammedi F, DeKoven JG, Alhusayen R. Pityriasis rosea-like eruptions following vaccination with BNT162b2 mRNA COVID-19 vaccine. Dermatol Ther. Only a few cases of pityriasis rosea (PR)/pityriasis rosea-like eruption (PRLE) after anti-SARS-CoV-2 vaccination have been reported. official website and that any information you provide is encrypted 2023 Mar 29;13(7):1286. doi: 10.3390/diagnostics13071286. Before Although histopathologic characteristics of PR are also observed in PR-like lesions, the presence of dyskeratotic keratinocytes, interface dermatitis, and eosinophilic infiltration in the dermis may be more prominent in PR-like eruptions (11). Physical examination revealed that lesions were distributed along cleavage lines, similar to PR, without herald patch or prominent scales (Figure 1C). Pityriasis rosea, pityriasis rosea-like eruptions, and herpes zoster in Coronavirus pandemic (COVID-19), McMahon D.E., Amerson E., Rosenbach M., et al. Dursun R, Temiz SA. Herald patch is often absent. Pityriasis rosea is a common skin disease that is not contagious. Keywords: Results were superimposable: parakeratosis, mild spongiosis, acanthosis and exocytosis were seen in the epidermis. 2022 Nov 1;43(6):555-558. doi: 10.2500/aap.2022.43.220058. SV, supervised the work. doi: 10.1111/dth.15602. 2021 Sep;34(5):e15040. An official website of the United States government. Moreover, while dermoscopy may facilitate the diagnosis of PR, its utility for atypical PR or PR-like lesions is still limited. eCollection 2022. doi: 10.1111/jdv.17342. He was otherwise healthy and taking no medications. eCollection 2022. Safety and efficacy of the BNT162b2 mRNA Covid-19 vaccine. The https:// ensures that you are connecting to the Pityriasis rosea-like cutaneous eruption as a possible dermatological manifestation after Oxford-AstraZeneca vaccine: Case report and brief literature review. Epub 2021 Aug 26. J Med Virol 2021; 93: 1850-1851. We include a review on all cases of PR/PRLE after anti- SARS-CoV-2 vaccination reported in the literature and discuss some pathogenetic hypotheses. Despite this rare complication, our report highlights that the presence of PR-like eruption is not a contraindication for subsequent vaccinations. Epub 2021 Jun 28. Drago F, Ciccarese G, Javor S, et al. Covid: Skin rashes are ONLY symptom for 21% patients, says KCL study Drago F, Ciccarese G, Rebora A, Parodi A. The face may be involved; involvement of the oral cavity occurs in 50% of patients. Would you like email updates of new search results? Unauthorized use of these marks is strictly prohibited. and transmitted securely. (A) Dermoscopic features: dotted and linear vessels forming a network on a yellowish background with some whitish peripheral scales (original magnification x20). Other plausible theories include molecular mimicry with viral epitopes and type IV delayed hypersensitivity reaction (12). PMC Variable dermatological manifestations including acral erythema, urticaria, vasculitis, vesicular or pustular eruptions, maculopapular rash have all been reported during the course of COVID19.